Sample Preparation for Single Cell Analysis: Tips and Tricks
Single cell analysis is a powerful technique for characterizing complex tissue types, identifying rare cell populations, uncovering regulatory relationships between genes, and tracking cell...
View ArticleEnvision New Dimensions: Introducing the Visium Spatial Gene Expression Solution
The ability to discern spatial gene expression differences in complex biological systems is critical to our understanding of developmental biology and the progression of disease. However, the...
View ArticleThe Human Microbiome: Beyond the Gut
The human microbiome has been linked to health and disease. Recent improvements in and better accessibility to high-throughput screening have transformed scientists' ability to perform research in this...
View ArticleAccelerating Protein Purification by Using Thermal Unfolding as a Guiding Tool
Cellular expression and purification of proteins are among the most widely used techniques in biology. Expressing proteins in stable, properly-folded states is a challenge that may be abated by...
View ArticleStem Cell for In Vitro Modeling of Neurological Disease
Stem cells are valuable for neurological disease research and drug development as they permit the in vitro construction of disease models. Human pluripotent stem cells (hPSCs), including human induced...
View ArticleWinning Westerns: Proven Strategies to Optimize Your Western Blots
Does Western blotting give you more trouble than expected? Do you feel like your precious samples are being wasted on bad Westerns? Join MilliporeSigma and find out how you can improve your Western...
View ArticleGenomic Analysis: Steering Clinical Trials
Genotyping during the active study phase of clinical trials is becoming more popular because of lower costs and the availability of high-throughput microarray platforms that quickly provide accurate...
View ArticleGene-Modulation Technologies in the Development of Cell-Based Therapies
Cell therapy, especially adoptive T-cell transfer, is an active area of cancer research and treatment. Although promising, many challenges from efficacy to safety remain.Horizon Discovery harnesses...
View ArticleInvestigating Targeted CD3 Activation in Cytotoxic T cells via Immune...
Immune checkpoint inhibitors promote anti-tumor immune responses by enhancing T-cell activity. Measuring the pharmacodynamic effects of these drug types presents a challenge as both the immune and...
View ArticleHow Centrifugal Devices Facilitate Molecular Biology Research
Biomolecule purification involves a complex series of steps where target purity and recovery are vital. Many common nucleic acid and protein handling procedures can benefit from the use of centrifugal...
View ArticleRare Genetic Disease: Models and Mechanisms
Establishing research models for any human disease is tricky business - more so for rare genetic diseases such as ataxia, telangiectasia, progeria, Paget’s disease, and Rett syndrome. Researchers...
View ArticleBattling the Bugs: Mitigating Cell Culture Contamination
Ensuring cell culture sterility is essential in small and large bioprocesses. Microbial contamination from bacteria, viruses, and fungi can spread among experiments and workflows—wasting time,...
View ArticleSimplifying Patient Participation in Research Studies
Research depends on samples from patients and healthy volunteers. However, obtaining biospecimens from human subjects can be a challenge for researchers and patients alike. Home-based specimen...
View ArticleCAR T-Cell Therapy: Overcoming Toxicities
Following the success of the first checkpoint inhibitors for treating cancer, many researchers are now turning their attention to chimeric antigen receptor (CAR) T cell therapy. This novel treatment...
View ArticleFrom Ancient Recipes to the Blood of Komodo Dragons: The Quest for a Solution...
The search for solutions to the antibiotic resistance problem is moving beyond traditional antibiotic drugs, leading researchers to some unexpected places. The Scientist is bringing together a panel of...
View ArticleThe One and Only: Single-Cell Resolution of Autoimmune Disorders
Heterogeneous disorders such as autoimmune diseases are challenging to study using conventional sequencing techniques. The immune response is complex, and important mechanisms in single cells may be...
View ArticleCrucial Applications of Single Cell Gene Expression and Immune Profiling for...
The ongoing coronavirus (COVID-19) outbreak has taken thousands of lives, and the number of infections is growing daily. In this webinar sponsored by 10x Genomics, Brian Fritz will discuss the utility...
View ArticleAutomate Your Entire Multiplexed ELISA Workflow to Increase Work-Away Time
The new CodePlex Secretome solution uses one system for a faster approach with significantly less sample volume to obtain highly multiplexed cytokine data. Load just 11 µL per sample replicate and walk...
View ArticlePrecious Cargo: Extracellular Vesicles in Cancer Research
Cellular turnover, tissue injury, and malignancy all cause nucleic acid release into the bloodstream. These cell-free nucleic acids can circulate around the body inside extracellular vesicles, which...
View ArticleResolving Cell Subtype Specialization with scRNA-seq and RNAscope
Discover how a combination of single-cell RNA sequencing (scRNA-seq) and quantitative RNA in situ hybridization (RNAscope) resolves molecular specialization of cell subtypes. Using scRNA-seq and...
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